发明名称 |
Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity |
摘要 |
In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention. |
申请公布号 |
US8791061(B2) |
申请公布日期 |
2014.07.29 |
申请号 |
US201213457162 |
申请日期 |
2012.04.26 |
申请人 |
Soligenix, Inc. |
发明人 |
Donini Oreola;Rozek Annett;Lentz Shannon Wayne |
分类号 |
A61K38/00;C07K5/10 |
主分类号 |
A61K38/00 |
代理机构 |
Lewis Kohn & Fitzwilliam LLP |
代理人 |
Lewis Kohn & Fitzwilliam LLP ;Kohn David M.;Moyer-Henry Kari |
主权项 |
1. An isolated peptide consisting of the amino acid sequence of RRVP (SEQ. ID. NO: 62), or a pharmaceutical salt, ester or amide thereof. |
地址 |
Princeton NY US |