Therapy-enhancing glucan

摘要

This invention provides a composition comprising an effective amount of glucan capable of enhancing efficacy of antibodies. This invention further provides the above compositions and a pharmaceutically acceptable carrier. This invention also provides a method for treating a subject with cancer comprising administrating the above-described composition to the subject. This invention provides a composition comprising effective amount of glucan capable of enhancing efficacy of vaccines. This invention also provides a method of treating a subject comprising administrating the above pharmaceutical composition to the subject. This invention provides a composition comprising effective amount of glucan capable of enhancing efficacy of natural antibodies. This invention provides a composition comprising effective amount of glucan capable of enhancing host immunity. This invention also provides a composition comprising effective amount of glucan capable of enhancing the action of an agent in preventing tissue rejection.

主权项

1. A method of treating cancer in a subject, comprising:
(a) administering a complement-activating antibody to said subject, and (b) orally administering to said subject a β-(1,3)-glucan in an amount effective to enhance the anti-tumor effect of said antibody, wherein said antibody and said glucan alone has little or no effect on said cancer, and wherein said glucan has a molecular weight from about 40,000 to about 359,000 Daltons.