The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
申请公布号
CA2518669(C)
申请公布日期
2014.07.29
申请号
CA20042518669
申请日期
2004.03.11
申请人
GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人
BIEMANS, RALPH;GORAJ, CARINE;MERTENS, EMMANUEL;VANDERCAMMEN, ANNE
