发明名称 |
METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS, SCLERODERMA, AND MYOSITIS WITH AN ANTIBODY AGAINST INTERFERON-ALPHA. |
摘要 |
<p>The disclosure relates to methods of treating systemic lupus erythematosus, scleroderma, and myositis comprising the administration of an anti-interferon-alpha antibody. Specifically, the disclosure provides weight-based and fixed dose administration regimes based on pharmacokinetic characteristics. Further disclosed are sequences of complementarity determining regions (CDRs) of heavy chain and light chain variable regions of the antibody. The methods of suppressing an interferon (I FN) pharmacodynamic signature are also provided.</p> |
申请公布号 |
MX2013013785(A) |
申请公布日期 |
2014.07.28 |
申请号 |
MX20130013785 |
申请日期 |
2012.05.23 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
RYAN CRISTE;LORIN ROSKOS;WENDY WHITE;DOMINIQUE ETHGEN (FALLECIDO);RAJESH NARWAL;GABRIEL ROBBIE |
分类号 |
A61K39/395;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|