发明名称 |
AMINO ACID DERIVATES FUNCTIONALIZED ON THE N- TERMINAL CAPABLE OF FORMING DRUG INCAPSULATING MICROSPHERES. |
摘要 |
Described herein are compounds and compositions that are characterized by the Markush formulae (I), (II), (III), (IV), (V), and (VI) underneath, where at least one terminal amino group is further functionalized by bearing a group of type (i), (ii), or (iii). Such compounds are obtained by reacting a terminal or internal amino group with epoxides, acrylates, or aldehydes bearing lipophilic groups. The resulting amino acid, peptide, polypeptide-lipids (named "APPLs" in the application) are deemed useful as drug delivery systems including nucleotide delivery to cells. Formulae (i), (ii), and (iii). |
申请公布号 |
MX2014005072(A) |
申请公布日期 |
2014.07.28 |
申请号 |
MX20140005072 |
申请日期 |
2012.10.26 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
CHEN, YI;ANDERSON, DANIEL GRIFFITH;LOVE, KEVIN THOMAS;DONG, YIZHOU;LANGER. ROBERT S.;CHEN, DELAI;VEGAS, ARTURO JOSE;ALABI, AKINLEYE;ZHANG, YUNLONG |
分类号 |
C07D207/16;A61K48/00;C07C227/18;C07C229/12;C07C229/16;C07C229/22;C07C229/26;C07C229/28;C07D209/20;C07D233/64;C07D241/08;C07D403/06;C07D487/06;C12N15/87 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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