NOVEL CHLOROGENIC ACID DERIVATIVES AND COMPOSITION FOR TREATING INFLAMMATORY DISEASE COMPRISING THE SAME

摘要

The present invention relates to a novel chlorogenic acid derivative compound having anti-inflammatory activities and to an anti-inflammatory composition including the same as an active ingredient. The chlorogenic acid derivative compound of the present invention controls the overproduction of nitrogen oxide (NO) derived by the treatment of LPS in histiocytes. The chlorogenic acid derivative compound of the present invention inhibits the activation of NF-κB which is an important signal transmittal intermediated transcription factor in oxidant stress and inflammation promoting routes. The chlorogenic acid derivative compound of the present invention has a high possibility of being developed into an agent for treating various inflammatory diseases by inhibiting the overproduction of NO and the activation of NF-κB.