| 摘要 |
FIELD: veterinary medicine.SUBSTANCE: method of production of water-soluble polymer anthelmintic preparations from water-insoluble substances is characterised in that the anthelmintic substance and polyvinylpyrrolidone with a low molecular weight with Mw of 12700±2700 in gram equivalent ratio of 70:30 is taken and stirred thoroughly under draft in a mortar or in a chemical reactor with a mixer of any type for 10-30 minutes, adding gradually to the mixture 40-70 parts by weight of acetone or ethyl alcohol per 100 parts by weight of the mixture of polyvinylpyrrolidone and anthelmintic substance, the obtained homogeneous mass is dried and milled to form the powder with 70% of particle size less than 5-9 mcm.EFFECT: invention provides obtaining of complex chemical polymer anthelmintic preparations in which the unsubstituted therapeutically active groups of anthelmintic substances are maintained, at that the preparations acquire solubility in water, their bioavailability is increased, the therapeutic activity of anthelmintic is retained at 2-3-fold lower doses.7 tbl, 8 ex |
