DIAGNOSTIC TECHNIQUE FOR POSTVACCINAL IMMUNITY TO DIPHTHERIA IN CHILDREN LIVING ON TERRITORY OF EXPOSURE TO HAZARDOUS CHEMICAL FACTORS

摘要

FIELD: medicine.SUBSTANCE: invention involves the following stages: chemical environmental contaminants targeting the immune system on the territory of residence are listed. For the listed contaminants, a risk of immune disorders is assessed by a hazard index. If HI is more than 1.0, the children living in the specified conditions and vaccinated up to a schedule and/or re-vaccinated with a DPT vaccine - diphtheria and tetanus toxoids and pertussis vaccine - and suffering from no immune diseases are selected. Blood is sampled from the above children; the sample is examined to measure an amount of the specified chemical environmental contaminants to detect individuals with the above amount exceeding an ambient regional level by not less than 20%; an amount of postvaccinal immunoglobulin G (IgG) antibodies to diphtherial anatoxin is measured in the blood serum of the selected individuals by ELISA with specific test-systems. The individuals with the above amount being less than the protective level are selected and assigned with a correlation of the above antibodies from the blood concentration of the listed chemicals, and if stating the reliable relations simultaneously: high blood concentration of lead more than 0.04 mg/dmand of o-cresol more than 0 mg/dmand lower concentration of postvaccinal IgG antibodies to diphtherial anatoxin as compared to the protective level, a decrease of the postvaccinal immunity to diphtheria is diagnosed in the child.EFFECT: applying the invention enables providing the reliable diagnosis of the postvaccinal immunity in the children exposed to chemical environmental toxic agents on the territory of living.2 dwg, 4 tbl