发明名称 |
METHOD FOR PROVIDING HIGHER EFFICACY AND SAFETY OF ULTRAFAST OPIOID DETOXIFICATION |
摘要 |
FIELD: medicine.SUBSTANCE: what is involved is infusion therapy with crystalloid solutions at 15 ml/kg of a patient's body weight. That is followed by puncturing and catheterising an epidural space at the level of ThVII-ThVIII according to the standard practice and introducing a test dose of 2% lidocaine 3 ml. If observing no signs of intrathecal introduction of local anaesthetics 10 minutes later, a basic dose containing 0.75-1% naropin 10 ml or 0.25-0.5% marcaine 10 ml and clofelin 3-5 mcg/kg is introduced. Total intravenous anaesthesia follows 20 minutes after pre-medication with atropine 0.01 mg/kg, 1% diphenylhydramine 1 ml and relanium 10 mg and urethral catheterisation. A narcosis is induced with propofol in a dose of 2 mg/kg. Anaesthesia is maintained with propofol 2-4 mg/kg·h. After that, within the first hour following the detoxification, naloxone 12 mg is introduced intravenously; a naloxone measurement rate is supposed to make 0.8 mg/h for 4-5 following hours of general anaesthesia. The repeated introduction of 0.75-1% naropin 6 ml or 0.25-0.5% marcaine 6 ml and clofelin 2-3 mcg/kg into the epidural space is performed 90 minutes later. After the procedure is terminated, and the patient recovers, prolonged epidural analgesia is conducted by introducing 0.2% naropin 10 ml and clofelin 1 mcg/kg into the epidural space every 4 hours for 24-48 hours.EFFECT: method provides safety of ultrafast opioid detoxification and prolongs the remission in the given category of patients.1 ex |
申请公布号 |
RU2524421(C1) |
申请公布日期 |
2014.07.27 |
申请号 |
RU20120153304 |
申请日期 |
2012.12.10 |
申请人 |
GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "VOLGOGRADSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET" MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJSKOJ FEDERATSII" |
发明人 |
TUROVETS MIKHAIL IVANOVICH |
分类号 |
A61M19/00;A61K31/05;A61K31/135;A61K31/165;A61K31/167;A61K31/4168;A61K31/46;A61K31/5513;A61P23/00 |
主分类号 |
A61M19/00 |
代理机构 |
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代理人 |
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