发明名称 |
Uso de pertuzumab, trastuzumab y quimioterapia para tratar cancer de mama her2 positivo, cancer gástrico her2 positivo y adenocarcinoma metastásico o inoperable her2 positivo; bolsa intravenosa que contiene pertuzumab y trastuzumab para tratar cancer. |
摘要 |
The present application describes uses for and articles of manufacture including Pertuzumab, a first-in-class HER2 dimerization inhibitor. In particular, the application describes methods for extending progression free survival in a HER2-positive breast cancer patient population; combining two HER2 antibodies to treat HER2-positive cancer without increasing cardiac toxicity; treating early-stage HER2-positive breast cancer; treating HER2-positive cancer by co-administering a mixture of Pertuzumab and Trastuzumab from the same intravenous bag; treating HER2-positive metastatic gastric cancer; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and Vinorelbine; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and aromatase inhibitor; and treating low HER3 ovarian, primary peritoneal, or fallopian tube cancer. It also describes an article of manufacture comprising a vial with Pertuzumab therein and a package insert providing safety and/or efficacy data thereon; a method of making the article of manufacture; and a method of ensuring safe and effective use of Pertuzumab related thereto. In addition the application describes an intravenous (IV) bag containing a stable mixture of Pertuzumab and Trastuzumab suitable for administration to a cancer patient. |
申请公布号 |
CL2014000889(A1) |
申请公布日期 |
2014.07.25 |
申请号 |
CL20140000889 |
申请日期 |
2014.04.09 |
申请人 |
GENENTECH, INC. |
发明人 |
ALAVATTAM SREEDHARA;AMLER LUKAS C;DE TOLEDO PELIZON CHRISTINA H;BENYUNES MARK C;CLARK EMMA L;KWONG GLOVER ZEPHANIA W;MITCHELL LADA;RATNAYAKE JAYANTHA;ROSS GRAHAM A;WALKER RU-AMIR |
分类号 |
A61K39/395;A61P35/00;C07K16/32 |
主分类号 |
A61K39/395 |
代理机构 |
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