Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

摘要

Disclosed is the use of an NGF antibody (4D4) in the manufacture of a medicament for treating a condition caused by increased expression of NGF or increased sensitivity to NGF, - wherein the NGF antibody comprises a light chain comprising SEQ ID. NO. 44 and a heavy chain comprising SEQ ID. NO. 40 as defined in the complete specification; - wherein the NGF antibody dose is selected from the group consisting of 3 mg, 10 mg, and 20 mg; - wherein the medicament is for use orally, through injection by intravenous, intraperitoneal, intracerebral, intra-parenchymal, intracerebroventricular, intramuscular, intra-ocular, intraarterial, intraportal, intralesional or subcutaneous routes, by sustained release systems, or by implantation devices; and - wherein the condition is osteoarthritis (OA) knee pain, acute pain, dental pain, pain from trauma, surgical pain, pain resulting from amputation or abscess, causalgia, demyelinating diseases, trigeminal neuralgia, cancer, chronic alcoholism, stroke, thalamic pain syndrome, diabetes, acquired immune deficiency syndrome (”AIDS”), toxins, chemotherapy, general headache, migraine, cluster headache, mixed-vascular or non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, lupus, osteoarthritis, fibromyalgia, inflammatory bowel disorders, irritable bowel syndrome, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, sunburn, carditis, dermatitis, myositis, neuritis, collagen vascular diseases, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia or allodynia, diabetic neuropathy pain, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, colitis, gastric ulceration, duodenal ulcers, vasomotor or allergic rhinitis, or bronchial disorders, dysmenorrhoea, dyspepsia, gastroesophageal reflux, pancreatitis, or visceralgia.