| 摘要 |
The present disclosure relates to substituted triazolopyridine compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds. Compounds of the disclosure include: 2-(4-fluorophenyl)-N-[4-(2-{[2 -methoxy-4-(2-oxa-6-azaspiro[3.3]hept-6-ylcarbonyl)phenyl]amino} [1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide, 4-{[6-(4-{[(4-fluorophenyl)acetyl]amino }phenyl) [1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(oxetan-3-yl)benzamide, 2-(4-fluorophenyl)-N-{ 4-[2-({4-[(3-hydroxyazetidin-1-yl)carbonyl]-2-(2,2,2-trifluoroethoxy)phenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl}acetamide, And 2-(4-fluorophenyl)-N-[4-(2-{[4-(2-oxa-6-azaspiro[3.3]hept-6-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide, |
