| 摘要 |
The present invention provides an anti-human FOLR1 antibody against diseases associated with human FOLR1-expressing cells, which specifically recognizes and binds to an amino acid sequence of human FOLR1 or a conformational structure thereof and also has a high effector activity such as antibody-dependent cellular cytotoxicity activity (ADCC activity). The present invention can provide a monoclonal antibody which specifically recognizes and binds to the amino acid sequence of human FOLR1 or the conformational structure thereof and also has ADCC activity and CDC activity, or an antibody fragment thereof, a DNA encoding the antibody, a vector comprising the DNA, a transformant obtained by introducing the vector, a method for producing the antibody or the antibody fragment thereof using the transformant, and a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment as an active ingredient. |
| 主权项 |
1. A monoclonal antibody or an antibody fragment thereof that competes with one antibody selected from the following (a)-(c) to specifically recognize human FOLR1 and binds to an epitope identical to the epitope on human FOLR1 to which the antibody binds, and also shows an anti-tumor activity:
(a) an antibody in which complementarity determining regions (hereinafter, referred to as CDRs) 1-3 of heavy chain (hereinafter, referred to as H chain) of the antibody comprise the amino acid sequences represented by SEQ ID NOs. 30, 31, and 32, respectively and CDRs 1-3 of light chain (hereinafter, referred to as L chain) of the antibody comprise the amino acid sequences represented by SEQ ID NOs. 33, 34, and 35, respectively; (b) an antibody in which CDRs 1-3 of H chain of the antibody comprise the amino acid sequences represented by SEQ ID NOs. 30, 31, and 32, respectively and CDRs 1-3 of L chain of the antibody comprise the amino acid sequences represented by SEQ ID NOs. 33, 34, and 35, respectively, and cysteine in the amino acid sequence represented by SEQ ID NO. 32 (CDR3 of antibody H chain) is substituted with threonine, methionine, isoleucine, valine, phenylalanine, or glutamine, regarding the antibody; and (c) an antibody in which H chain of the antibody comprises the amino acid sequence represented by SEQ ID NO. 98, and L chain of the antibody comprises the amino acid sequence represented by SEQ ID NO. 94. |
