| 主权项 |
1. A compound of the formula I or a stereoisomer of the compound of the formula I and mixtures of these forms in any ratio, where X is —C(O)— or —SO2—, U is oxygen atom, sulfur atom, NH, —C(O)—NH— or —(C0-C4)-alkylene-, A is oxygen atom, sulfur atom, NH, —C(O)—NH— —NH—C(O)—, —NR2- or —(C0-C4)-alkylene-, V is 1) —(C2-C9)-alkylene-, where alkylene is unsubstituted or substituted independently of one another once, twice or three times by —OH, NH2 or halogen, 2) —(C1-C2)-alkylene-(C3-C6)-cycloalkyl-(C1-C2)-alkylene-, where cycloalkyl is substituted independently of one another once, twice or three times by R15, or 3) —(C3-C9)-alkenylene-, D is —(C1-C2)-alkylene-, Y is 1) covalent bond, 2) —(C3-C12)-cycloalkyl, where cycloalkyl is substituted independently of one another once, twice or three times by R15, 3) —(C6-C14)-aryl, where aryl is unsubstituted or substituted independently of one another once, twice or three times by R15, or 4) Het, where Het means a 4- to 15-membered heterocyclic ring system having 4 to 15 ring atoms which are present in one, two or three ring systems which are connected together, and which comprise, depending on the ring size, one, two, three or four identical or different heteroatoms from the series oxygen, nitrogen or sulfur, and in which Het is unsubstituted or substituted independently of one another once, twice or three times by a —(C1-C3)-alkyl, halogen, —NH2, —CF3 or —O—CF3, R1 is 1) hydrogen atom, 2) —(C1-C6)-alkyl, 3) —(C1-C6)-alkyl-OH, 4) —(C0-C4)-alkyl-(C3-C6)-cycloalkyl, 5) —(C1-C10)-alkyl-O—C(O)—O—R2, 6) —(CH2)r—(C6-C14)-aryl, in which aryl is unsubstituted or substituted independently of one another once, twice or three times by R15, and r is the integer zero, 1, 2 or 3, or 7) —(CH2)s-Het, where Het means a 4- to 15-membered heterocyclic ring system having 4 to 15 ring atoms which are present in one, two or three ring systems which are connected together, and which comprise, depending on the ring size, one, two, three or four identical or different heteroatoms from the series oxygen, nitrogen or sulfur, and in which Het is unsubstituted or substituted independently of one another once, twice or three times by R15, and s is the integer zero, 1, 2 or 3, R2 is 1) —(C1-C6)-alkyl, 2) —(CH2)r—(C6-C14)-aryl, in which aryl is unsubstituted or substituted independently of one another once, twice or three times by R15, and r is the integer zero, 1, 2 or 3, or 3) —(C0-C4)-alkyl-(C3-C6)-cycloalkyl, R3 is 1) —(C2-C6)-alkylene-NH2, where alkylene is unsubstituted or substituted once, twice, three or four times by halogen, 2) —(C1-C4)-alkylene-O—(C1-C4)-alkylene-NH2, 3) —(C1-C4)-alkylene-SO2—(C1-C4)-alkylene-NH2, 4) —(C0-C4)-alkylene-Het, where Het is as defined above and is substituted by —NH2 and once, twice or three times by R15, 5) —(C0-C4)-alkylene-(C3-C8)-cycloalkyl-NH2 or 6) —(C0-C6)-alkylene-cyclic amine, wherein the cyclic amine is chosen from the group consisting of azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl azepinyl, morpholinyl and thiomorpholinyl; R6 is 1) hydrogen atom, 2) —(C1-C6)-alkyl, where alkyl is unsubstituted or substituted independently of one another once, twice or three times by R16, 3) —O—(C1-C6)-alkyl, where alkyl is unsubstituted or substituted independently of one another once, twice or three times by R16, 4) —(C0-C4)-alkylene-Het, where Het is as defined above, where alkylene and Het are unsubstituted or substituted independently of one another once, twice or three times by R16, 5) —(C0-C4)-alkylene-aryl, where alkylene and aryl are unsubstituted or substituted independently of one another once, twice or three times by R16, 6) —(C0-C4)-alkylene-(C3-C8)-cycloalkyl, where alkylene and cycloalkyl are unsubstituted or substituted independently of one another once, twice or three times by R16, R7 is hydrogen atom, halogen or —(C1-C6)-alkyl, R8 is hydrogen atom, halogen or —(C1-C6)-alkyl, R9 is hydrogen atom, halogen or —(C1-C6)-alkyl, R15 is hydrogen atom, —(C1-C4)-alkyl, —O—CF3, —NH2, —OH, —CF3 or halogen, and R16 is —O—CF3, —NH2, —OH, —CF3 or halogen; or a physiologically tolerated salt thereof; with the proviso that compounds where U is O; A is O; V is substituted or unsubstituted —(C4)-alkylene-; D is —(C1)-alkylene- and Y is substituted or unsubstituted 1,4-phenylene are excluded; with the further proviso that compounds where; U is O and V, A, Y and D taken together form a C8 linker are excluded. |
