| 发明名称 |
OLIGOOXOPIPERAZINES FOR p53 REACTIVATION |
| 摘要 |
The present invention relates to oligooxopiperazines for reactivating p53. Methods of using the oligooxopiperazines are also disclosed. |
| 申请公布号 |
US2014205655(A1) |
申请公布日期 |
2014.07.24 |
| 申请号 |
US201414160037 |
申请日期 |
2014.01.21 |
| 申请人 |
New York University ;The Regents of the University of Michigan ;The Ohio State University Research Foundation |
发明人 |
ARORA Paramjit S.;PAN Quintin;MAPP Anna |
| 分类号 |
C07D403/06;A61K45/06;A61K31/496 |
主分类号 |
C07D403/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or preventing in a subject a disorder mediated by interaction of E6 with CREB-binding protein and/or p300, said method comprising:
administering to the subject an oligooxopiperazine that substantially mimics helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α under conditions effective to treat or prevent the disorder. |
| 地址 |
New York NY US |
