发明名称 |
Targeting of chondroitin sulfate glycans |
摘要 |
The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA). |
申请公布号 |
AU2013217986(A1) |
申请公布日期 |
2014.07.24 |
申请号 |
AU20130217986 |
申请日期 |
2013.02.08 |
申请人 |
VAR2 PHARMACEUTICALS APS |
发明人 |
SALANTI, ALI;THEANDER, THOR GRUNDTVIG;DAUGAARD, MADS;NIELSEN, MORTEN;DAHLBACK, MADELEINE;CLAUSEN, THOMAS MANDEL |
分类号 |
C07K14/445;A61K39/015 |
主分类号 |
C07K14/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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