RECOMBINANT MICROORGANISMS AND METHODS OF USE THEREOF

摘要

The invention relates to methods for the production of chemical compounds, particularly but not exclusively ethanol, by microbial fermentation. Also described are genetically modified micro-organisms capable of using carbon monoxide to produce one or more products, particularly but not exclusively ethanol as a main product, and producing a reduced amount or substantially no 2,3-butanediol and/or a precursor thereof.

主权项

1. A recombinant carboxydotrophic acetogenic microorganism which is adapted to produce one or more product and a reduced amount or substantially no 2,3 butanediol and/or a precursor thereof upon fermentation of a substrate comprising carbon monoxide, the microorganism comprising one or more genetic modification which disrupts the 2,3-butanediol biosynthesis pathway compared to a parental microorganism.