HETEROCYCLIC PYRIDONE COMPOUND, AND INTERMEDIATE, PREPARATION METHOD AND USE THEREOF

摘要

The present invention relates to a heterocyclic pyridone compound represented by General Formula (I), where the heterocyclic pyridone compound is used as a tyrosine kinase inhibitor, and particularly a c-Met inhibitor. The present invention also relates to intermediates for preparing heterocyclic pyridone compound and a preparation method. The present invention further relates to a pharmaceutical composition containing the heterocyclic pyridone compound as an active ingredient, and a use of the pharmaceutical composition in treatment of diseases associated with tyrosine kinase c-Met, especially cancer associated with c-Met, as a medicament.

主权项

1. A heterocyclic pyridone compound, being a compound represented by General Formula (I): wherein R1 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl and C(═O)NR10R11; R2 is selected from hydrogen, halogen, alkoxy, amino, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxy alkyl, amino alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, heterocyclic group, and substituted heterocyclic group; R3 is selected from hydrogen, halogen, alkyl and heteroaryl; R4 is selected from groups having Structural Formulas (1) to (5) below, wherein Z═CH or N; R5 is selected from NH2, NH(C═O)R12, NHC(═O)NR10R11, O(CH2)nOR12 (n is 1 to 4), NR10R11 or a a heterocyclic ring and an aromatic heterocyclic ring; R6, R7, R8, R9, R10, R11, R12 are simultaneously or non-simultaneously selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, substituted aminoalkyl, substituted alkylamino, arylamino, substituted arylamino, heteroaryl amino, substituted heteroaryl amino, a heterocyclic group and a substituted heterocyclic group; W and X are selected from CH and N; and is selected from groups having Structural Formulas (6) to (38) below: wherein R13, R14 and R15 are independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkoxyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, substituted aminoalkyl, substituted alkylamino, arylamino, substituted arylamino, heteroaryl amino, substituted heteroaryl amino, a heterocyclic group and a substituted heterocyclic group.