SELENO-COMPOUNDS AND THERAPEUTIC USES THEREOF

摘要

The present invention relates to compounds and compositions useful as antioxidants and in particular to selenium containing compounds of formula (I): wherein n is 1, 2, or 3; m is 2, 3, 4, or 5; and each R] is independently —(optionally substituted C1-C3 alkylene) p-OH, where p is 0 or 1, or a salt thereof. The invention also relates to the use of these seleno-compounds in the treatment of diseases or conditions associated with increased levels of oxidants produced by myeloperoxidase (MPO), such as for instance, atherosclerosis.;

主权项

1. A compound of formula (I):wherein n is 1, 2, or 3; m is 2, 3, 4, or 5; and each R1 is independently (optionally substituted C1-C3 alkylene)p-OH, where p is 0 or 1, or a salt thereof.