USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN

摘要

The present invention refers to the use of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodysplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I″) for the treatment and/or prophylaxis of cancer of an organ.

主权项

1. A method for the treatment or prophylaxis of a hematological dyscrasia or for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy, comprising administering to a subject in need thereof, an effective amount of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof; wherein the compound of Formula (I′) is: wherein:
R1 is —(CH2)aY or —CH═CH—(CH2)pY;Y is —SO3H, —SO3−.X+, —SO3R3, —PO3H, —PO3—.X+, —PO3R3, —CO2H, —CO2−.X+ or —CO2R3, wherein when Y is —SO3H, —SO3−.X+ or —SO3R3, then R9 and R9′ are independently selected from —OH and —OR2, wherein at least one of R9 and R9′ is a substituted or unsubstituted alkylsulfonyloxy group, a substituted or unsubstituted arylsulfonyloxy group, a substituted or unsubstituted alkylcarbonyloxy group or a substituted or unsubstituted arylcarbonyloxy group;X+ is an organic cation or an inorganic cation, such that the general charge of the compound is neutral;R9 and R9′ are independently selected from —OH and —OR2, wherein when R9 and R9′ are both —OR2, then said R9 and R9′ can be the same or different;R2 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylsulfonyl group, a substituted or unsubstituted arylsulfonyl group, a substituted or unsubstituted alkylcarbonyl group or a substituted or unsubstituted arylcarbonyl group;R3 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group;a is number selected from 0, 1, 2, 3, 4, 5 and 6; andp is an integer selected from 0, 1, 2, 3, 4, 5 and 6.