| 发明名称 |
INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL |
| 摘要 |
This disclosure describes novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain and respiratory conditions. |
| 申请公布号 |
US2014206650(A1) |
申请公布日期 |
2014.07.24 |
| 申请号 |
US201414160333 |
申请日期 |
2014.01.21 |
| 申请人 |
Cubist Pharmaceuticals, Inc. |
发明人 |
Lippa Blaise S.;Li Qingyi;Cheng Lily;Liu Christopher M.;Wrona Iwona E.;Metcalf, III Chester A.;Jackson Andrew J. |
| 分类号 |
C07F9/09;C07D473/08 |
主分类号 |
C07F9/09 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:wherein,
R1 is hydrogen or —CH2—R1a, wherein R1a is a phosphate moiety; R2 is hydrogen or CH3; R3 is CH3 or CF3; and A is N or CH. |
| 地址 |
Lexington MA US |
