主权项 |
1. A peptidic compound having the formula (I):
R1—Z—R2 (I) wherein Z is a peptide moiety having the formula (II)Tyr-Aib-X3-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-X12-Gln-X14-X15-X16-X17-X18-X19-X20-X21-Phe-Ile-Glu-Trp-Leu-Lys-X28-X29-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-X40 (II) X3 represents an amino acid residue selected from Gln, Glu and His, X12 represents an amino acid residue selected from Ile and Lys, X14 represents an amino acid residue having a side chain with an —NH2 group, wherein the —NH2 side chain group is functionalized by —C(O)—R5, wherein R5 may be a moiety comprising up to 50 or up to 100 carbon atoms and optionally heteroatoms selected from halogen, N, O, S and/or P, X15 represents an amino acid residue selected from Asp and Glu, X16 represents an amino acid residue selected from Ser, Lys, Glu and Gln, X17 represents an amino acid residue selected from Arg, Lys, Glu, Gln, Leu, Aib, Tyr and Ala, X18 represents an amino acid residue selected from Ala and Arg, X19 represents an amino acid residue selected from Ala and Val, X20 represents an amino acid residue selected from Gln, Aib, Lys and His, X21 represents an amino acid residue selected from Asp, Glu and Leu, X28 represents an amino acid residue selected from Asn and Ala, X29 represents an amino acid residue selected from Gly, Thr and D-Ala, X40 is either absent or represents Lys, R1 represents NH2, R2 represents the C-terminal group of the peptidic compound and is selected from OH and NH2, or a salt or solvate thereof. |