| 发明名称 |
ENGINEERED POLYPEPTIDE AGENTS FOR TARGETED BROAD SPECTRUM INFLUENZA NEUTRALIZATION |
| 摘要 |
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them. |
| 申请公布号 |
US2014206603(A1) |
申请公布日期 |
2014.07.24 |
| 申请号 |
US201414163882 |
申请日期 |
2014.01.24 |
| 申请人 |
Massachusetts Institute of Technology |
发明人 |
Sasisekharan Ram;Viswanathan Karthik;Soundararajan Venkataramanan;Raguram S.;Sasisekharan Viswanathan;Subramanian Vidya |
| 分类号 |
C07K14/00;G01N33/569 |
主分类号 |
C07K14/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An infold agent that binds a hemagglutinin (HA) polypeptide, which infold agent comprises a polypeptide less than about 1000 amino acids in length, which polypeptide has an amino acid tertiary fold backbone populated by interaction residues selected and arranged so that, when the infold agent is in the vicinity of the binding site, individual interaction residues are positioned within a preselected distance or volume of cognate target residues. |
| 地址 |
Cambridge MA US |
