METHODS OF PROMOTING FAT LOSS COMPRISING ADMINISTERING AN ALK7 INHIBITOR

摘要

The invention relates to ALK7 soluble receptors and their uses as antagonists of the function of certain ligands such as GDF-8 (Myostatin) and GDF-11. The ALK7 soluble receptor of the invention is useful as antagonists of GDF-8 and GDF-11 in the treatment of neuronal diseases or conditions such as stroke, spinal cord injury, and all peripheral nerve diseases. The ALK7 soluble receptor of the invention is also useful as GH (growth hormone) equivalent, and for increasing muscle mass.

主权项

1. A method for promoting fat loss in a mammal, the method comprising administering to a mammal in need thereof a pharmaceutical preparation comprising a polypeptide that comprises a ligand binding domain of an ALK7 receptor, wherein the polypeptide selectively binds myostatin relative to BMP3 and competes with an ALK7 receptor to bind myostatin, wherein the preparation is substantially free of pyrogenic materials.