POLYPEPTIDE THAT BINDS ABERRANT CELLS AND INDUCES APOPTOSIS

摘要

Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers.

主权项

1. A proteinaceous molecule comprising:
at least one domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex, functionally connected with a substance that induces apoptosis in aberrant cells, but not normal cells.