| 摘要 |
<p>The invention relates to immunoglobulin single variable domain molecules which bind serum albumin comprising modifications and/or mutations which allow reduced binding to pre-existing ADAs and, in particular, wherein the immunoglobulin single variable domain molecules are human VH or Camelid VHH. Fusion proteins, ligands, compositions, nucleic acid, vectors and hosts are also described.</p> |
| 申请人 |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENTLIMITED |
发明人 |
ASHMAN, CLAIRE;BIRCHLER, MARY;DE WILDT, RUDOLF M T;FRIEL, SARAH;HOLLAND, MARIE CLAIRE H;LEWIS, ALAN PETER;MORLEY, PETER JOSEPH;SANDAL, THOMAS;SCHON, OLIVER;STEWARD, MICHAEL |
