| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for improving the pharmacokinetics of an antigen-binding molecule, a method for increasing the number of times for the antigen-binding molecule to bind to an antigen, an antigen-binding molecule improved in pharmacokinetics, an antigen-binding molecule improved in the number of times for antigen-binding molecule to bind to an antigen, and methods for producing those.SOLUTION: This antigen-binding molecule has a value of KD(pH 5.8)/KD(pH 7.4), a ratio of KD at pH 5.8 to KD at pH 7.4, to an antigen, of 2 or more. There is provided a method for improving the pharmacokinetics of an antigen-binding molecule by weakening the antigen-binding activity of the antigen-binding molecule at pH 5.8 more than that the antigen-binding activity at pH 7.4. |
