| 主权项 |
1. A compound having the structure of formula I: or pharmaceutically acceptable salt thereof, wherein: R1 is selected from a group consisting of —C1-9alkyl, —C2-9alkenyl, —C2-9alkynyl, —NR9R10, —C1-9alkylR11, —C2-9alkenylR11, —C2-9alkynylR11, -carbocyclyl-R11, —CH(OH)C1-9alkylR9, —CH(OH)C2-9alkenylR9, —CH(OH)C2-9alkynylR9, —CH(OH)carbocyclyl-R9, —C(═O)R9, —C(═O)C1-9alkylR9, —C(═O)C2-9alkenylR9, —C(═O)C2-9alkynylR9, —C(═O)carbocyclyl-R9, —C(═O)NR9R10, —N(R9)C(═O)R9, —N(R9)C(═O)NR9R10, —N(R9)C(═O)OR9, —N(R9)C(═O)C(═NR10)R9, —N(R9)C(═O)C(═CR9R10)R9, —N(R9)C(═O)C1-4alkylN(R9)C(═O)R9, —N(R9)C(═NR10)R9, —C(═NR10)NR9R10, —N═C(R9)NR9R10, —N(R9)SO2R9, —N(R9)SO2NR9R10, —N═CHR9, —C(R9R10)C(═O)NR9R10, —C(R9R10)N(R9)C(═O)R9, —C(R9R10)OR9, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, and substituted or unsubstituted heterocyclyl; G1 is selected from a divalent group consisting of —C(RaRb)—, —C(═Ra′)—, —C(RaRb)C(RcRd)—, —C(Ra)═C(Rc)—, —C(═O)C(RaRb)—, —C(RaRb)C(═O)—, and a bond; G2 is selected from a divalent group consisting of —C(ReRf)—, —C(═Re′)—, ═C(Re)—, —C(ReRf)C(RgRh)—, —C(ReRf)C(RgRh)C(RiRj)—, —C(═O)—, —C(═O)C(ReRf)—, —C(ReRf)C(═O)—, —C(═O)C(ReRf)C(RgRh)—, —C(ReRf)C(RgRh)C(═O)—, —C(═O)C(ReRf)C(RgRh)C(RiRj)—, —C(ReRf)C(RgRh)C(RiRj)C(═O)—, —C(Re)═C(Rg)—, —C(Re)═C(Rg)C(RiRj)— and —C(ReRf)C(Rg)═C(Rj)—; Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, and Rj are independently selected from a group consisting of H, Cl, F, CN, CF3, —R9, —OR9, NR9R10, —C(═O)NR9R10, and —C(═O)OR9, or independently: Ra and Rc, Re and an R7, Re and R6, Rk and Rc, Rk and Re, Re and Rg, and Rg and Rj are taken together with the atoms to which they are attached and any intervening atoms to form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, or independently Re and Rf are taken together with the atoms to which they are attached and any intervening atoms to form a substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl; Ra′ and Re′ are ═CR9R10 or independently Ra′ and Rk, or Re′ and Rk, are taken together with the atoms to which they are attached to form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl; Z is selected from a divalent group consisting of —C(R9R10)—, —O—, —S—, —N(R9)—, —N[C(═O)R9]—, —N[C(═O)NR9R10]—, —N[C(═O)OR9]—, —N[C(═NR10)R9]—, —N[SO2R9]—, —N[SO2NR9R10]—, —N(R9)C(═O)—, —C(R9Rk)—, —C(═Rk)—, —N(Rk)—, and a bond; Rk and Rc, Rk and Re, Ra′ and Rk, or Re′ and Rk are taken together with any intervening atoms to form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl; Y is selected from a group consisting of N, CR6, and C, with the proviso that when Z is a bond, —C(R9R10)—, —C(R9Rk)—, or —C(═Rk)—, then Y is N; R6 is selected from a group consisting of H, —C1-9alkyl, —C2-9alkenyl, —C2-9alkynyl, carbocyclyl, —C1-9alkylR11, —C2-9alkenylR11, —C2-9alkynylR11, carbocyclyl-R11, —C(═O)OR9 and —C1-9alkylCO2R9, —C2-9alkenylCO2R9, —C2-9alkynylCO2R9, and -carbocyclyl-CO2R9, or alternatively R6 and an R7 or R6 and Re are taken together with the atoms to which they are attached and any intervening atoms to form a substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl; each R7 is independently selected from a group consisting of H, halo, —C1-9alkyl, —C2-9alkenyl, —C2-9alkynyl, —NR9R10, —OR9, —C1-9alkylCO2R9, —C2-9alkenylCO2R9, —C2-9alkynylCO2R9, and -carbocyclyl-CO2R9, or independently, R6 and an R7 or an R7 and an R8 are taken together with the atoms to which they are attached and any intervening atoms to form a substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, or independently an R7 and Re are taken together with intervening atoms to form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl; each R8 is independently selected from a group consisting of H, halo, —C1-9alkyl, —C2-9alkenyl, —C2-9alkynyl, —NR9R10, —OR9, —C1-9alkylCO2R9, —C1-9alkylCO2R9, —C2-9alkenylCO2R9, —C2-9alkynylCO2R9, and -carbocyclyl-CO2R9, or independently, an R7 and an R8 are taken together with the atoms to which they are attached to form a substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, or independently, each R8 attached to a ring atom forming part of a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl is absent; each R9 is independently selected from a group consisting of H, —C1-9alkyl, C2-9alkenyl, —C2-9alkynyl, carbocyclyl, —C1-9alkylR11, C2-9alkenylR11, —C2-9alkynylR11, -carbocyclyl-R11, —C1-9alkylCO2R12, C2-9alkenylCO2R12, —C2-9alkynylCO2R12, -carbocyclyl-CO2R12, —C1-9alkyl-N(R12)OR12, C2-9alkenyl-N(R12)OR12, —C2-9alkynyl-N(R12)OR12, -carbocyclyl-N(R12)OR12, —C1-9alkyl-OR12, C2-9alkenyl-OR12, —C2-9alkynyl-OR12, -carbocyclyl-OR12, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, and substituted or unsubstituted heterocyclyl; each R10 is independently selected from a group consisting of H, —C1-9alkyl, —OR9, —CH(═NH)—, —C(═O)OR9, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, and substituted or unsubstituted heterocyclyl; each R11 is independently selected from a group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl, and substituted or unsubstituted heterocyclyl; each R12 is independently selected from a group consisting of H, C1-9alkyl, —(CH2)0-3—R11, —C(R13)2OC(O)C1-9alkyl, —C(R13)2OC(O)R11, —C(R13)2OC(O)OC1-9alkyl and —C(R13)2OC(O)OR11; each R13 is independently selected from a group consisting of H and C1-4alkyl; each X is independently selected from a group consisting of H, —CO2R12, and carboxylic acid isosteres; m is independently zero or an integer from 1 to 2; the bond represented by a dashed and solid line represents a bond selected from the group consisting of a single bond and a double bond; and each C1-9alkyl, C2-9alkenyl, and C2-9alkynyl is optionally substituted. |
