| 发明名称 |
SIGNAL-SENSOR POLYNUCLEOTIDES |
| 摘要 |
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules. |
| 申请公布号 |
US2014206852(A1) |
申请公布日期 |
2014.07.24 |
| 申请号 |
US201314135876 |
申请日期 |
2013.12.20 |
| 申请人 |
MODERNA THERAPEUTICS, INC. |
发明人 |
Hoge Stephen G.;de Fougerolles Antonin;Chakraborty Tirtha |
| 分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated synthetic signal-sensor polynucleotide, wherein said isolated synthetic signal-sensor polynucleotide comprises an mRNA which encodes an oncology-related polypeptide of interest and a sensor sequence comprising SEQ ID NO: 3741. |
| 地址 |
CAMBRIDGE MA US |
