DETECTION OF INFERTILITY RISK AND PREMATURE OVARIAN AGING

摘要

Method of early detection of risk of infertility and ovarian aging in and treatment of a human female who has not experienced infertility and is not otherwise indicated to have premature ovarian aging. A number of CGG repeats on each allele of the isolated FMR1 gene is measured by using an assay, and a testing regimen is performed only when the determined number of CGG repeats on one of the FMR1 gene alleles is less than 26. The testing regimen includes periodically measuring serum level of a hormone related to fertility, such as Anti-Müllerian Hormone, Follicle Stimulating Hormone and/or estradiol over a period of about three to eight years and, after each measurement, determining if the measured serum level is less than a set confidence interval for a human female of the same age of the female. If so, the human female is treated for premature ovarian aging.

主权项

1. A method of treating a human female to reduce the risk of infertility, comprising:
isolating an FMR1 gene from the human female; measuring the number of CGG repeats on each allele of the isolated FMR1 gene by using an assay; determining that the number of CGG repeats on at least one of the alleles of the isolated FMR1 gene is less than 26; measuring the human female's level of a hormone related to fertility; repeating the measurement of the human female's level of a hormone related to fertility multiple times during an approximately three to approximately eight year period following the measurement of the number of CGG repeats; after each measurement, determining if the hormone level is outside the normal range for a human female of the age of the female at the time of the measurement, and administering an FMR1 inhibitor to the human female to block expression of the human female's FMR1 gene when it is determined that the level is outside the normal range for a human female of the age of the female at the time of the measurement.