发明名称 |
CELL-DERIVED VIRAL VACCINES WITH LOW LEVELS OF RESIDUAL CELL DNA BY BETA-PROPIOLACTONE TREATMENT |
摘要 |
<p>The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as ²-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.</p> |
申请公布号 |
EP1951296(B2) |
申请公布日期 |
2014.07.23 |
申请号 |
EP20060831855 |
申请日期 |
2006.11.01 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS GMBH |
发明人 |
GREGERSEN, JENS-PETER;KOST, HOLGER |
分类号 |
A61K39/13;A61K39/145 |
主分类号 |
A61K39/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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