| 发明名称 |
SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF |
| 摘要 |
The present invention relates to a (2R, 3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process. |
| 申请公布号 |
EP2671878(A4) |
申请公布日期 |
2014.07.23 |
| 申请号 |
EP20120742093 |
申请日期 |
2012.01.31 |
| 申请人 |
SHANGHAI INSTITUTE MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;TOPHARMAN SHANGHAI CO., LTD. |
发明人 |
ZHANG, QIANG;ZHANG, RONGXIA;TIAN, GUANGHUI;LI, JIANFENG;ZHU, FUQIANG;JIANG, XIANGRUI;SHEN, JINGSHAN |
| 分类号 |
C07D263/26;C07C17/16;C07C22/04;C07C29/159;C07C33/20;C07C51/06;C07C57/30;C07C209/08;C07C209/50;C07C209/62;C07C231/02;C07C231/08;C07C231/12;C07C303/28;C07C309/66;C07D263/62 |
主分类号 |
C07D263/26 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
