| 摘要 |
<p>Provided is an anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒP-X 1 -X 2 -P-G-E€ƒ€ƒ€ƒ€ƒ€ƒ(1)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒX 3 -X 4 -X 5 -F-Y-X 6 -L-X 7 -P-X 8 €ƒ€ƒ€ƒ€ƒ€ƒ(2)
(wherein, X 1 represents L, V, N, T, S, M, or R; X 2 represents F, Y, or M; X 3 represents V or G; X 4 represents N or S; X 5 represents Q, P, or S; X 6 represents S, T, or I; X 7 represents A or S; and X 8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.</p> |
