发明名称 |
N-SUBSTITUTED HETEROCYCLYL CARBOXAMIDES |
摘要 |
A compound of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Ra, A, B, D and E are all as defined herein. The compounds modulate the activity of CFTR and are useful in the treatment of inflammatory or obstructive airways diseases or mucosal hydration, including, for example cystic fibrosis. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. |
申请公布号 |
EP2755652(A1) |
申请公布日期 |
2014.07.23 |
申请号 |
EP20120783311 |
申请日期 |
2012.09.14 |
申请人 |
NOVARTIS AG |
发明人 |
BALA, KAMLESH, JAGDIS;BUDD, EMMA;EDWARDS, LEE;HOWSHAM, CATHERINE;LEGRAND, DARREN, MARK;TAYLOR, ROGER, JOHN |
分类号 |
A61K31/415;A61K31/4439;A61K31/497;A61P11/06 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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