Method of inhibiting regulatory T-cell activity by administering an antibody that inhibits interleukin 35

摘要

Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.

主权项

1. A method of inhibiting a regulatory T-cell function in a subject, comprising administering to a subject in need of inhibiting a regulatory T-cell function a therapeutically effective amount of a specific binding agent, wherein said specific binding agent comprises an antibody that inhibits Interleukin 35 (IL35) activity, wherein the therapeutically effective amount of said antibody inhibits a regulatory T-cell function in said subject.