发明名称 Aqueous liquid preparations and light-stabilized aqueous liquid preparations
摘要 An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized with a water-soluble metal chloride, is provided.
申请公布号 US8784789(B2) 申请公布日期 2014.07.22
申请号 US200310500354 申请日期 2003.07.30
申请人 Senju Pharmaceutical Co., Ltd. 发明人 Higashiyama Masayo
分类号 A61K31/4545;A61K47/02;A61K9/00 主分类号 A61K31/4545
代理机构 Wenderoth, Lind & Ponack, LLP 代理人 Wenderoth, Lind & Ponack, LLP
主权项 1. An aqueous liquid preparation consisting of, in an aqueous solution, an active ingredient consisting of (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid or a pharmacologically acceptable acid addition salt thereof; a water-soluble metal chloride in a light-stabilizing effective amount; water; and optionally at least one material selected from the group consisting of a buffer, a preservative, a chelating agent, and a flavor; wherein the metal chloride has a concentration selected from the range of a lower limit concentration of 0.2 w/v % and an upper limit concentration of 1.2 w/v %.
地址 Osaka JP