Method of prognosis associated with cases of postpartum hemorrhage

摘要

Novel prognosis methods associated with cases of postpartum haemorrhage providing a predictive test enabling practitioners to provide better management of patients suffering from postpartum haemorrhage. Different risk factors exist on which a score allowing prediction of the need to carry out invasive procedures to stop bleeding has been developed.

主权项

1. An in vitro prognosis method for halted bleeding in a patient suffering from postpartum haemorrhage without any invasive procedure, comprising the following steps:
a) determining with an assay apparatus the plasmatic fibrinogen concentration, troponin I blood concentration and prothrombin time from a biological sample of said patient; b) examining at least two clinical markers of said patient chosen from the group consisting of heart rate and the presence of placentation anomalies; c) calculating a Z score as per the following formula: Z=a+b+c+d+e,
i) where a is associated with the existence of placentation anomalies in said patient, with a having a value of 0 if no placental anomaly is observed in said patient, and a having a value of 1 if one or more placentation anomalies are observed in said patient;ii) where b is associated with the heart rate of said patient, with b having a value of 0 if the heart rate of said patient is less than or equal to 15 bpm (beats per minute) and b having a value of 1 if the heart rate is higher than 115 bpm;iii) where c is associated with the plasmatic fibrinogen concentration of said patient, with c having a value of 0 if said level is equal to or higher than 2 g/L and c having a value of 1 if said level is lower than 2 g/L;iv) where d is associated with the blood troponin I concentration of said patient, with d having a value of 0 when said concentration is lower than 0.02 ng/L, and d having a value of 1 if said concentration is higher than or equal to 0.02 ng/L;v) where e is associated with the prothombin time (PT) of said patient, e having a value of 0 if said prothrombin time is higher than or equal to 50%, and e having a value of 1 if said prothrombin time is less than 50%;wherein a Z score higher than or equal to a value of 2 is indicative of the need to carry out invasive procedure to stop bleeding in said patient suffering from postpartum haemorrhage.