Method of using beta-hydroxy-beta-methylbutyrate for treating disease-associated wasting

摘要

The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.

主权项

1. A method of treating disease-associated wasting of a patient comprising administering to the patient a composition comprising:
a. beta-hydroxy-beta-methylbutyrate, its salts, metabolites or derivatives thereof; b. carnitine; and c. an amino nitrogen source enriched with large neutral amino acids; wherein the composition is substantially lacking in free amino acids; and wherein the disease-associated wasting is associated with a disease selected from the group consisting of cachexia, cancer, age-associated wasting, wasting associated with long-term hospital stay, HIV/AIDS, arthritis, trauma, liver disease, Crohn's disease, inflammatory bowel diseases, renal insufficiency, and chronic obstructive pulmonary disease.