Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same

摘要

Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.

主权项

1. A method of inhibiting CD4-mediated signaling in a subject comprising administering to said subject an effective amount of a compound of Formula (IV), (V), or (VI), or a pharmaceutically acceptable salt thereof.