Lyophilization cakes of proteasome inhibitors

摘要

Lyophilized cakes of proteasome inhibitors are described, as well as methods for their production and use.

主权项

1. A lyophilized cake comprising:
(a) a compound of Formula I or a pharmaceutically acceptable salt or ester thereof: wherein R1 is an optionally substituted 5-, 6-, or 10-membered heteroaryl having at least one N or R1 is an optionally substituted 6- or 10-membered aryl; (b) a cyclodextrin; and (c) a bulking agent comprising a monosaccharide.