| 发明名称 | Antibodies which bind factor VIII | ||
| 摘要 | The invention, in general, features a method of treatment and/or prevention of a thrombotic pathological condition, in a mammal, which includes administering to the mammal in need of such treatment a therapeutically effective amount of a composition including an antibody directed against the C1 domain of Factor VIII, which is a partially inhibitory antibody of Factor VIII. | ||
| 申请公布号 | US8784816(B2) | 申请公布日期 | 2014.07.22 |
| 申请号 | US201213658365 | 申请日期 | 2012.10.23 |
| 申请人 | Life Sciences Research Partners VZW | 发明人 | Jacquemin Marc G.;Saint-Remy Jean-Marie R. |
| 分类号 | A61K39/395;C07K16/36 | 主分类号 | A61K39/395 |
| 代理机构 | Nixon & Vanderhye P.C. | 代理人 | Nixon & Vanderhye P.C. |
| 主权项 | 1. An isolated monoclonal antibody directed against factor VIII which is partially inhibiting factor VIII procoagulant activity, wherein said antibody is comprising: heavy chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 33, 34 and 35, respectively, and light chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 36, 37 and 38, respectively; or heavy chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 39, 40 and 41, respectively, and light chain variable region CDR1, CDR2 and CDR3 corresponding to SEQ ID NOs: 42, 43 and 44, respectively; or an antigen-binding fragment of any of said antibodies. | ||
| 地址 | Leuven BE | ||