| 摘要 |
Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof are provided. Specifically, dipeptidyl peptidase IV inhibitors presented by following formula (I) are provided. Such compounds can be used for treating or preventing the diseases associated with dipeptidyl peptidase IV, such as diabetes, obesity and hyperlipemia. The compounds presented by formula (I) and pharmaceutically acceptable salts thereof, a method for preparing a pharmaceutical composition thereof and their uses in the manufacture of medicaments for treating or preventing the disease associated with dipeptidyl peptidase IV are provided.; |
| 主权项 |
1. A compound according to formula (I) or optical isomers, crystal forms, pharmaceutically acceptable inorganic or organic salts, hydrates or solvates thereof: wherein, X is selected from the group consisting of: (1) —C1-C3 alkylidene; (2) —C(O)—; (3) —S(O)2—; (4) —C(O)O—; and (5) —C(O)NR1—; R is selected from the group consisting of: (1) H; (2) C1-C6 alkyl, which is unsubstituted or substituted by one to three substituents selected from the following group: fluorine, chlorine or hydroxyl; (3) C3-C6 cycloalkyl, which is unsubstituted or substituted by one to two substituents selected from the following group: C1-C3 alkyl, fluorine, chlorine, hydroxyl, cyano, C(O)NH2; (4) Phenyl, which is unsubstituted or substituted by one to three substituents selected from the followings: C1-C3 alkyl, fluorine, chlorine, cyano, S(O)2R2; and (5) 6-membered heterocycle containing one to two atoms independently selected from N atom, above-mentioned 6-membered heterocycle is unsubstituted or substituted by one to three substituents selected from the followings: C1-C3 alkyl, fluorine, chlorine, cyano, S(O)2R2; wherein, R1 is H or C1-C3 alkyl;R2 is C1-C3 alkyl. |
