发明名称 |
Cosmetic use of apolipoprotein D type proteins |
摘要 |
The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation.;The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis. |
申请公布号 |
US8785397(B2) |
申请公布日期 |
2014.07.22 |
申请号 |
US200812602246 |
申请日期 |
2008.06.20 |
申请人 |
L'Oreal |
发明人 |
Bernard Dominique;Castiel Isabelle;Simonetti Lucie |
分类号 |
A61K38/16;A61K8/64;G01N33/68 |
主分类号 |
A61K38/16 |
代理机构 |
Oliff PLC |
代理人 |
Oliff PLC |
主权项 |
1. A method for characterizing the state of an epithelium comprising at least steps consisting in:
a) determining in a sample of the epithelium a content of a polypeptide having the amino acid sequence of SEQ ID NO:2, and b) comparing the content determined in step a) to a reference value which is the content of the polypeptide obtained from an epithelium sample of a normal skin, the state of the epithelium being ageing, the state being characterized by a decrease between the reference value and the content determined in step a). |
地址 |
Paris FR |