COMPOSIÇÃO COM FÓRMULA GERAL I, COMPOSTO COM A FÓRMULA II, ANTICORPO, MÉTODO DE PRODUÇÃO DE INIBIDOR DE METALOPROTEINASE,COMPOSIÇÃO FARMACÊUTICA, MÉTODO DE TRATAMENTO DE DOENÇA ASSOCIADA A ATIVIDADE INCOMPATÍVEL OU ANORMAL DE METALOPROTEINAS, MÉTODO DE INIBIÇÃO DA ATIVIDADE DA METALOPROTEINASE MATRIZ EM UMA CÉLULA

摘要

The present invention relates to a compound having the general Formula (I): wherein: m and n are each independently an integer from 1 to 6; X1-X3 and Y1-Y3 are each independently O or S; R1-R3 are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and R is (CH2)x-C(═O)NR′—(CH2)y-NR′R″ whereas: x and y are each independently an integer from 1 to 6; and R′ and R″ are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and to an antibody comprising an antigen recognition region capable of specifically binding the above compound.