Compositions and assays for treatment and diagnosis of helicobacter pylori infection and conditions

摘要

Methods of diagnosing Helicobacter pylori infection or associated conditions are based in part on the correlation of the presence of a α-L-fucosidase 2 marker with the infection. Methods and compositions for treating or preventing Helicobacter pylori infection or associated conditions are based in part on administering an α-L-fucosidase 2 inhibitor to an infected subject or a subject at risk of developing the infection.

主权项

1. A method of inhibiting or arresting development of an infection caused by a Helicobacter pylori strain, the method comprising:
administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of an α-L-fucosidase 2 inhibitor, anda pharmaceutically acceptable carrier, excipient or diluent;wherein
the Helicobacter pylori strain is resistant to Amoxicillin, Clarithromycin or Levofloxacin.