System and method for providing closed loop infusion formulation delivery

摘要

A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

主权项

1. A method for delivering an insulin formulation, the method comprising:
taking a plurality of samples of a blood glucose level over a period of time; calculating a rate at which the blood glucose level of the plurality of samples is rising or falling over time; comparing said calculated rate to a predefined threshold rate; and disabling the delivery of the insulin formulation if the calculated rate is rising at a rate less than the predefined threshold rate, wherein the insulin formulation is delivered as a bolus.