| 发明名称 | T cell receptors and related materials and methods of use | ||
| 摘要 | The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials. | ||
| 申请公布号 | US8785601(B2) | 申请公布日期 | 2014.07.22 |
| 申请号 | US201013146531 | 申请日期 | 2010.01.25 |
| 申请人 | The United States of America, as represented by the Secretary, Department of Health and Human Services | 发明人 | Rosenberg Steven A.;Morgan Richard A.;Frankel Timothy L.;Peng Peter |
| 分类号 | C07K16/00;C07K17/00;A61K39/00 | 主分类号 | C07K16/00 |
| 代理机构 | Leydig, Voit & Mayer | 代理人 | Leydig, Voit & Mayer |
| 主权项 | 1. A T cell receptor (TCR) comprising the amino acid sequences of SEQ ID NO: 1-6 and 18-19. | ||
| 地址 | Washington DC US | ||