主权项 |
1. A compound corresponding to formula I: wherein n is 0, 1, 2, 3 or 4; R1 and R2 together denote —CH═CH—N═CH—, which is attached in any desired direction to the parent structure; or R2 and R3 together denote a residue selected from the group consisting of —CH═CH—CH═N—; —CH═CH—N═CH—; —CR68═CR69—CH═N—; and —CR68═CR69—N═CR70—, which is attached in any desired direction to the parent structure; or R3 and R4 together denote a residue selected from the group consisting of —CH═CH—CH═N—; —CH═CH—N═CH—; —CR68═CR69—CH═N—; and —CR68═CR69—N═CR70—, which is attached in any desired direction to the parent structure; or R4 and R5 together denote —CH═CH—N═CH—, which is attached in any desired direction to the parent structure; and the remaining residues of R1, R2, R3, R4 and R5 each independently represent H; F; Cl; Br; I; —SF5; —NO2; —CN; —NH2; —OH; —SH; —C(═O)—NH2; —S(═O)2—NH2; —C(═O)—NH—OH; —C(═O)—OH; —C(═O)—H; —S(═O)2—OH; —C(═NH)—NH2; —C(═NH)—NH—R9; —N═C(NH2)2; —N═C(NHR10)(NHR11); —O—P(═O)2—O—R12; —NHR13; —NR14R15; —NH—C(═O)—R13; —OR16; —SR17; —C(═O)—NHR18; —C(═O)—NR19R20; —S(═O)2—NHR21; —S(═O)2—NR22R23; —C(═O)—OR24; —C(═O)—R25; —S(═O)—R26; —S(═O)2—R27 or a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; R6 denotes H or a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; R7 denotes hydrogen or —OH; or R6 and R7 together with the carbon atom to which they are attached form a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted 3-, 4-, 5-, 6- or 7-membered cycloaliphatic residue; R8 denotes —SF5; —O—CF3; —CF3; —O—CFH2; —O—CF2H; —CFH2; —CF2H; or an unsubstituted, monosubstituted or polysubstituted tert.-butyl residue; T denotes C—R35; U denotes C—R36; V denotes N, and W denotes C—R38; or T denotes C—R35; U denotes N; V denotes C—R37, and W denotes C—R38; or T denotes N; U denotes C—R36; V denotes C—R37, and W denotes C—R38; or T denotes N; U denotes N; V denotes C—R37, and W denotes C—R38; or T denotes N; U denotes C—R36; V denotes N, and W denotes C—R38; or T denotes C—R35; U denotes N; V denotes N, and W denotes C—R38; or T denotes C—R35; U denotes C—R36; V denotes C—R37, and W denotes C—R38; R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26 and R27 each independently denote a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; or
an unsaturated or saturated, unsubstituted, monosubstituted or polysubstituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic residue optionally comprising at least one heteroatom as a ring member, wherein said cycloaliphatic residue optionally may be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system, or optionally may be attached via a linear or branched, unsubstituted, monosubstituted or polysubstituted C1-6 alkylene group or 2- to 6-membered heteroalkylene group, or both; oran unsubstituted, monosubstituted or polysubstituted 5- to 14-membered aryl or heteroaryl residue, which optionally may be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system, or optionally may be attached via a linear or branched, unsubstituted, monosubstituted or polysubstituted C1-6 alkylene group or 2- to 6-membered heteroalkylene group, or both; R35, R36 and R37 each independently denote H; F; Cl; Br; I; —SF5; —NO2; —CF3; —CN; —NH2; —OH; —SH; —C(═O)—NH2; —S(═O)2—NH2; —C(═O)—NH—OH; —C(═O)—OH; —C(═O)—H; —S(═O)2—OH; —NHR13; —NR14R15; —NH—C(═O)—R13; —OR16; —SR17; —C(═O)—NHR18; —C(═O)—NR19R20; —S(═O)2—NHR21; —S(═O)2—NR22R23; —C(═O)—OR24; —C(═O)—R25; —S(═O)—R26; —S(═O)2—R27; or a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; or
an unsubstituted, monosubstituted or polysubstituted 5- to 14-membered aryl or heteroaryl residue, which optionally may be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system, or optionally may be attached via a linear or branched, unsubstituted, monosubstituted or polysubstituted C1-6 alkylene group or C2-6 alkenylene group or C2-6 alkynylene group, or both; R38 denotes —NR40R41; —OR42; or —SR43; R40, R41, R42, and R43 each independently denote a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; or
an unsaturated or saturated, unsubstituted, monosubstituted or polysubstituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic residue optionally comprising one or more heteroatom(s) as ring member(s), wherein said cycloaliphatic residue optionally be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system, or optionally may be attached via a linear or branched, unsubstituted, monosubstituted or polysubstituted C1-6 alkylene group or 2- to 6-membered heteroalkylene group, or both; oran unsubstituted, monosubstituted or polysubstituted 5- to 14-membered aryl or heteroaryl residue, which optionally may be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system, or optionally may be attached via a linear or branched, unsubstituted, monosubstituted or polysubstituted C1-6 alkylene group or 2- to 6-membered heteroalkylene group, or both; or R40 and R41 together with the nitrogen atom to which they are attached form a saturated or unsaturated or unsubstituted heterocycloaliphatic residue or a 4-, 5-, 6-, 7-, 8- or 9-membered heterocycloaliphatic residue substituted with 1, 2, 3, 4 or 5 residues R57 and optionally comprising one or more further heteroatom(s) as ring member(s), wherein said heterocycloaliphatic residue optionally may be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system; R57 denotes —NHR58, —NR59R60; or a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; R58, R59 and R60 each independently denote —C(═O)—R61; or a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; or an unsubstituted, monosubstituted or polysubstituted 5- to 14-membered aryl or heteroaryl residue, which optionally may be fused with a saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted mono- or polycyclic ring system, or optionally may be attached via a linear or branched, unsubstituted, monosubstituted or polysubstituted C1-6 alkylene group or C2-6 alkenylene group or C2-6 alkynylene group, or both; R61 denotes a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; and R68, R69 and R70 each independently denote F, Cl, Br, I, or a linear or branched, saturated or unsaturated, unsubstituted, monosubstituted or polysubstituted aliphatic C1-10 residue; or a salt thereof; wherein:
said aliphatic C1-10 residues and tert.-butyl residues each optionally may be substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 substituents independently selected from the group consisting of F, Cl, Br, I, —CN, —NO2, —OH, —NH2, —SH, —O(C1-5-alkyl), —S(C1-5-alkyl), —NH(C1-5-alkyl), —N(C1-5-alkyl)(C1-5-alkyl), —C(═O)—O—C1-5-alkyl, —O—C(═O)—C1-5-alkyl, —O-phenyl, phenyl, —OCF3 and —SCF3;said 2- to 6-membered heteroalkylene groups, C1-6 alkylene groups, C2-6 alkenylene groups and C2-6 alkynylene groups each optionally may be substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 substituents independently selected from the group consisting of F, Cl, Br, I, —CN, —NO2, —OH, —NH2, —SH, —O(C1-5-alkyl), —S(C1-5-alkyl), —NH(C1-5-alkyl), —N(C1-5-alkyl)(C1-5-alkyl), —OCF3 and —SCF3;said heteroalkylene groups each optionally may comprise 1, 2 or 3 heteroatom(s) independently selected from the group consisting of oxygen, nitrogen as NH, and sulfur as chain link(s);said (hetero)cycloaliphatic residues each optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of —C1-6-alkylene-OH, ═CH2, —O—C1-5-alkylene-oxetanyl, —C1-5-alkylene-O—C1-5-alkylene-oxetanyl, —CH2—NH—C1-5-alkyl, —CH2—N(C1-5-alkyl)2, —N[—C(═O)—C1-5-alkyl]-phenyl, —CH2—O—C1-5-alkyl, oxo (═O), thioxo (═S), F, Cl, Br, I, —CN, —CF3, —SF5, —OH, —O—C1-5-alkyl, —O—C(═O)—C1-5-alkyl, —NH2, —NO2, —O—CF3, —S—CF3, —SH, —S—C1-5-alkyl, —C1-5-alkyl, —C(═O)—C1-5-alkyl, —C(═O)—OH, —C(═O)—O—C1-5-alkyl, —NH—C1-5-alkyl, —N(C1-5-alkyl)2, —NH-phenyl, —N(—C1-5-alkyl)-phenyl, cyclohexyl, cyclopentyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, piperidinyl, pyrrolidinyl, —(CH2)-pyridinyl, pyridinyl, —O-phenyl, —O-benzyl, phenyl and benzyl, wherein the cyclic moiety of the oxetanyl, (4,5)-dihydroisoxazolyl, thiazolyl, (1,2,5)-thiadiazolyl, thiophenyl, phenethyl, —N[—C(═O)—C1-5-alkyl]-phenyl, —NH-phenyl, —N(—C1-5-alkyl)-phenyl, —(CH2)-pyridinyl, pyridinyl, —O-phenyl, —O-benzyl, phenyl and benzyl residues optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —OH, —CF3, —SF5, —CN, —NO2, —C1-5 alkyl, —O—C1-5-alkyl, —O—CF3, —S—CF3, phenyl and —O-benzyl;unless otherwise stated, said (hetero)cycloaliphatic residues each optionally may comprise 1, 2 or 3 (further) heteroatom(s) independently selected from the group consisting of oxygen, nitrogen and sulfur;the rings of said mono- or polycyclic ring systems each optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═O), thioxo (═S),), F, Cl, Br, I, —CN, —CF3, —SF5, —OH, —O—C1-5-alkyl, —NH2, —NO2, —O—CF3, —S—CF3, —SH, —S—C1-5-alkyl, —C1-5-alkyl, —C(═O)—C1-5-alkyl, —C(═O)—OH, —C(═O)—O—C1-5-alkyl, —NH—C1-5-alkyl, —N(C1-5-alkyl)2, —O-phenyl, —O-benzyl, phenyl and benzyl, wherein the cyclic moiety of the —O-phenyl, —O-benzyl, phenyl and benzyl residues optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —OH, —CF3, —SF5, —CN, —NO2, —C1-5 alkyl, —O—C1-5-alkyl, —O—CF3, —S—CF3, phenyl and —O-benzyl;the rings of said mono- or polycyclic ring systems each are 5-, 6- or 7-membered and optionally may comprise 1, 2, 3, 4 or 5 heteroatom(s) as ring member(s), which are independently selected from the group consisting of oxygen, nitrogen and sulfur;said aryl or heteroaryl residues each optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —CN, —CF3, —SF5, —OH, —O—C1-5-alkyl, —NH2, —NO2, —O—CF3, —S—CF3, —SH, —S—C1-5-alkyl, —C1-5-alkyl, —C(═O)—OH, —C(═O)—C1-5-alkyl, —NH—C1-5-alkyl, —N(C1-5-alkyl)2, —NH—S(═O)2—C1-5-alkyl, —NH—C(═O)—O—C1-5-alkyl, —C(═O)—H, —C(═O)—C1-5-alkyl, —C(═O)—NH2, —C(═O)—NH—C1-5-alkyl, —C(═O)—N—(C1-5-alkyl)2, —O-phenyl, —O-benzyl, phenyl and benzyl, wherein the cyclic moiety of the —O-phenyl, —O-benzyl, phenyl and benzyl residues optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —OH, —CF3, —SF5, —CN, —NO2, —C1-5 alkyl, —O—C1-5-alkyl, —O—CF3, —S—CF3, phenyl and —O-benzyl; andsaid heteroaryl residues each optionally may comprise 1, 2, 3, 4 or 5 heteroatom(s) independently selected from the group consisting of oxygen, nitrogen and sulfur as ring member(s). |