发明名称 |
Pyrimidine derivatives as mTOR inhibitors |
摘要 |
The invention relates to compounds of formula (I);
wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. The compounds of formula (I) are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments. |
申请公布号 |
US8785457(B2) |
申请公布日期 |
2014.07.22 |
申请号 |
US201013256345 |
申请日期 |
2010.03.12 |
申请人 |
Cellzome Limited |
发明人 |
Lynch Rosemary;Cansfield Andrew David;Niblock Helen Sarah;Hardy Daniel;Scanlon Jane Elizabeth;Adrego Rita;Ramsden Nigel |
分类号 |
A61K31/5377;C07D413/04 |
主分类号 |
A61K31/5377 |
代理机构 |
|
代理人 |
Tomaska Margaret M.;Gimmi Edward R. |
主权项 |
1. A compound which is
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea, or a pharmaceutically acceptable salt thereof. |
地址 |
Cambridge GB |