| 主权项 |
1. A method for diagnosing and/or predicting the presence, progression and/or treatment effect of a disease characterized by retinal pathological changes in a subject, comprising the steps of:
(a) obtaining a retinal fundus image from the subject; (b) converting the image to a gray level image and/or extracting vessels from the image to obtain the gray level image and/or the vessel image; (c) performing statistical texture analysis on the gray level image and/or the vessel image, and generating one or more factors, wherein the statistical texture analysis includes using gray level co-occurrence matrix (GLCM) and/or run length matrix (RLM) to obtain texture features, including normalized Homogeneity, normalized Entropy, normalized Contrast, normalized 4th moment and normalized Run percentage; (d) comparing the one or more factors obtained from step (c) with those of a control, a change of the factors is an indication of the presence, progression and/or treatment effect of the disease in the subject. |
